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- Brodkey JA, Gates MA, Laywell ED, Steindler DA. The complex nature of interactive neuroregeneration-related molecules.
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- Janeczko K. The proliferative response of astrocytes to harm in neonatal rat mind.
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After a penetrating lesion in the central nervous system, astrocytes enlarge, divide, and participate in creating an surroundings that adversely affects neuronal regeneration. We have lately shown that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals were lesioned within the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one side, the lesions had been concomitantly infused with N-CAM or with one of the N-CAM-related molecules. As a control, a peptide of the identical composition as the N-CAM decapeptide however of random sequence was infused on the contralateral aspect of the mind. The inhibition was biggest in the cortical lesion websites (approximately 50%) and was much less pronounced within the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical sites infused with N-CAM continued to exhibit a significantly smaller inhabitants of dividing astrocytes than the sites on the alternative side.